opens up possibilities © 2017 Biogen. All rights reserved. 12/17 TEC-US-2495 • 225 Binney Street, Cambridge, MA 02142 • 1-800-456-2255 • TECFIDERA is a twice-daily pill proven to work against relapsing multiple sclerosis (MS) in 3 different ways. It can cut relapses in half, slow the development of brain lesions, and delay the progression of physical disability. In fact, in a 2-year study, people taking TECFIDERA were 38% less likely to experience physical disability progression than people taking placebo, and their risk of relapse was reduced by 49%. What is TECFIDERA? Tecfidera® (dimethyl fumarate) is a prescription medicine used to treat people with relapsing forms of multiple sclerosis. Important Safety Information Do not use TECFIDERA if you have had an allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing) to TECFIDERA or any of its ingredients. Before taking and while you take TECFIDERA, tell your doctor about any low white blood cell counts or infections or any other medical conditions. What are the possible side effects of TECFIDERA? TECFIDERA may cause serious side effects including: • Allergic reactions • PML, which is a rare brain infection that usually leads to death or severe disability. • Decreases in your white blood cell count. Your doctor should check your white blood cell count before you take TECFIDERA and from time to time during treatment • Liver problems. Your doctor should do blood tests to check your liver function before you start taking TECFIDERA and during treatment if needed. Tell your doctor right away if you get any symptoms of a liver problem during treatment, including: ° severe tiredness ° loss of appetite ° pain on the right side of your stomach ° dark or brown (tea color) urine ° yellowing of your skin or the white part of your eyes Important Safety Information (continued) The most common side effects of TECFIDERA include flushing and stomach problems. These can happen especially at the start of treatment and may decrease over time. Taking TECFIDERA with food may help reduce flushing. Call your doctor if these symptoms bother you or do not go away. Ask your doctor if taking aspirin before taking TECFIDERA may reduce flushing. These are not all the possible side effects of TECFIDERA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to Tell your doctor if you are pregnant or plan to become pregnant, or breastfeeding or plan to breastfeed. It is not known if TECFIDERA will harm your unborn baby or if it passes into your breast milk. Also tell your doctor if you are taking prescription or over-the-counter medicines, vitamins, or herbal supplements. If you take too much TECFIDERA, call your doctor or go to the nearest hospital emergency room right away. For additional Important Safety Information, please see Patient Information on the following page. This is not intended to replace discussions with your doctor. *Based on number of prescriptions from IMS NPA™ Weekly Data (September 27, 2013 – September 29, 2017). Laura S., living with relapsing MS Are you ready to say yes to fewer relapses? Visit or call 1-844-TalkTec (1-844-825-5832) Say yes to TECFIDERA—a pill that can cut MS relapses in half.