U.S. BLA 761053: Ocrelizumab—Genentech, Inc. Regional (Multiple Sclerosis): clean-label-text What are the possible side effects of OCREVUS? OCREVUS may cause serious side effects, including: • See “What is the most important information I should know about OCREVUS?” • Risk of cancers (malignancies) including breast cancer. Follow your healthcare provider’s instructions about standard screening guidelines for breast cancer. Most common side effects include infusion reactions and infections. See “What is the most important information I should know about OCREVUS?” These are not all the possible side effects of OCREVUS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. General information about the safe and effective use of OCREVUS. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use OCREVUS for a condition for which it was not prescribed. Do not give OCREVUS to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about OCREVUS that is written for health professionals. What are the ingredients in OCREVUS? Active ingredient: ocrelizumab Inactive ingredients: glacial acetic acid, polysorbate 20, sodium acetate trihydrate, trehalose dihydrate. Manufactured by: Genentech, Inc., A Member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080-4990 U.S. License No. 1048 For more information, go to www.OCREVUS.com or call 1-844-627-3887. This Medication Guide has been approved by the U.S. Food and Drug Administration Issued: 3/2017 ©2017 Genentech USA, Inc. All rights reserved. OCR/092716/0369 Printed in USA. 3/17