What is OCREVUS? OCREVUS is a prescription medicine used to treat adults with relapsing or primary progressive forms of multiple sclerosis. It is not known if OCREVUS is safe or effective in children. Who should not receive OCREVUS? Do not receive OCREVUS if you have an active hepatitis B virus (HBV) infection. Do not receive OCREVUS if you have had a life threatening allergic reaction to OCREVUS. Tell your healthcare provider if you have had an allergic reaction to OCREVUS or any of its ingredients in the past. What is the most important information I should know about OCREVUS? OCREVUS can cause serious side effects, including: • Infusion-related reactions: OCREVUS can cause infusion-related reactions that can be serious and require you to be hospitalized. You will be monitored during your infusion and for at least 1 hour after each infusion of OCREVUS for signs and symptoms of an infusion-related reaction. Tell your healthcare provider or nurse if you have any symptoms (see accompanying Patient Information). These infusion-related reactions can happen for up to 24 hours after your infusion. It is important that you call your healthcare provider right away if you have any of the signs or symptoms listed in the accompanying Patient Information. If you get infusion-related reactions, your healthcare provider may need to stop or slow down the rate of your infusion. • Infection: o OCREVUS increases your risk of getting upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes infections. Tell your healthcare provider if you have an infection or have any signs of infection (see accompanying Patient Information). These signs can happen during treatment or after you have received your last dose of OCREVUS. If you have an active infection, your healthcare provider should delay your treatment with OCREVUS until your infection is gone. o Progressive Multifocal Leukoencephalopathy (PML): Although no cases have been seen with OCREVUS treatment in clinical trials, PML may happen with OCREVUS. PML is a rare brain infection that usually leads to death or severe disability. Tell your healthcare provider right away if you have any new or worsening