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Pulmonary nodules, MS, and navigating the unknown

By Shambrekiá Wise

If you read my earlier article, you know I recently lost the battle with my staircase — and my dog could not have cared less. He trotted off to retrieve his treat like I hadn’t just reenacted an action movie stunt on the steps.

But that fall led me somewhere unexpected.

At the emergency room, while checking for fractures, something else appeared: a pulmonary nodule — one of those phrases that immediately sends your brain into “Google detective” mode.

A part of me couldn’t help researching whether there was any correlation between pulmonary nodules and multiple sclerosis. Not because I’m trying to give MS a bad rap — trust me, it doesn’t need my help — but because so many of the strange, inconvenient, or downright scary things that have happened in my body have shown up after my diagnosis.

Between the disease itself being immune-compromising and the medications lowering the body’s ability to fight infections, winter already feels like dodgeball season for viruses. So finding out I had a pulmonary nodule while also fighting the flu? Not fun. Not reassuring. Definitely not on my bingo card.

May or may not be related

So, is there a connection between MS and pulmonary nodules? The short answer: not typically. But there are rare, documented cases of immune-related lung nodules in people with MS — and that’s enough to make the average MS patient pause.

The NIH article I dug into describes a rare condition called pulmonary hyalinizing granuloma, which can show up as lung nodules and may be linked to abnormal immune responses. In one case, a woman with a 10-year history of MS developed nodular lesions in both lungs. After biopsy, the researchers noted: “The association of pulmonary hyalinizing granuloma with multiple sclerosis could be coincidental, but since there is a possibility of immune reaction in the pathogenesis of both diseases, the association may be significant.”

In other words:
  • It might be related.
  • It might not be.
  • The immune system is doing a lot in MS, and abnormalities in other tissues can sometimes be part of that story.
  • But PHG itself is very rare.
For most people with MS, pulmonary nodules — if they appear — are usually related to:
  • infections
  • past inflammation
  • scarring
  • environmental exposure
  • or completely unrelated coincidence
In fact, most pulmonary nodules found on CT scans turn out to be benign. I am thankful mine was and probably just related to a past run-in with an upper respiratory infection of some sort.

Where my mind actually went

Beyond the medical research, here’s what hit me hardest. How did I go from being perfectly fine, to a fall, to learning there’s something sitting in my lung?

MS teaches you a kind of hypervigilance. You’re always watching for “the next thing.” But this felt different — like my body was delivering news I didn’t ask for and definitely could not have ever expected.

A pulmonary nodule sounds huge. Terrifying even, but what actually matters (according to my doctors) is:
  • size
  • shape
  • growth
  • whether it shows signs of infection or immune reaction
My doctors will be monitoring it, and that alone helps me breathe a little easier.

Things MS patients should pay attention to:
  • New or worsening shortness of breath
  • Persistent cough
  • Chest discomfort
  • Recurrent respiratory infections
  • Fevers that keep returning
  • Fatigue that feels “different” from MS fatigue
  • Medication side effects that can weaken immune defenses
And after my fall, I’ll add:
  • Take stair safety seriously
  • Don’t walk with full hands
  • And for the love of stability, no socks on carpeted stairs
A bigger truth I’m learning

Not every new medical discovery is a catastrophe. Sometimes it’s just information. Sometimes it’s something to monitor. Sometimes it’s a fluke. Sometimes it’s your body saying, “Hey, I need some attention here.”

But for those of us living with MS, the emotional math is different. We experience new symptoms through a different lens — one shaped by uncertainty, caution, and the memory of everything MS has already introduced into our lives.

So here’s what I want other people with MS to know:
  • You’re not paranoid for asking questions. You’re informed.
  • You’re not overreacting. You’re paying attention.
  • And you’re not alone.
As for me? I’ll be monitoring this nodule, keeping my neurologist in the loop, and staying all the way off those stairs in socks. If MS is going to throw surprises at me, I’m at least going to stay upright while dealing with them.